Hydrochloric Acid → 5-Methylthiazole-4-carbohydrazide
反応式
[CH3:1][C:2]1[S:6][CH:5]=[N:4][C:3]=1[C:7]([NH:9][NH:10]C(OC(C)(C)C)=O)=[O:8].Cl>>[CH3:1][C:2]1[S:6][CH:5]=[N:4][C:3]=1[C:7]([NH:9][NH2:10])=[O:8]参加物
3
実験手順
A mixture of 1,1-dimethylethyl 2-[(5-methyl-1,3-thiazol-4-yl)carbonyl]hydrazinecarboxylate (544 mg, 2.114 mmol) in HCl (2643 μl, 10.57 mmol) (4M in 1,4-dioxane) was stirred at room temperature under an atmosphere of argon for 17 hours (overnight). After this time, the reaction mixture was concentrated under reduced pressure to give an off-white coloured solid of desired material in 162 mg.
後処理
- concentrationAfter this time, the reaction mixture was concentrated under reduced pressure
- customto give an off-white coloured solid of desired material in 162 mg
出典と根拠
- ORDレコード
- ord-e2023f0885fb4087886e93048a792ca3
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08501946B2
反応ノート
読み込み中…