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2-Methylpentane → 7-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-fluorophenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylpentane | HCID 7892 | — |
| 反応物 | Phenylboronic Acid | HCID 66827 | — |
| 反応物 | 4-Fluorophenylboronic acid | HCID 285645 | — |
| 反応物 | 7-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-phenyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine | HCID 66599191 | — |
| 生成物 | 7-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-fluorophenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine | HCID 66599261 | — |
反応手順
7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-fluorophenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine was prepared in a manner analogous to that described above for 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-phenyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine (Example 13), but using (4-fluorophenyl)boronic acid (commercially available e.g. from Alfa Aesar or ABCR) in the place of phenylboronic acid, and using MDAP followed by isohexane trituration rather than MDAP.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08501946B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-563509871d2442728096bbab9e7a54c6 |
| 出典メモ | uspto-grants-2013_08 |