Triethyloxonium tetrafluoroborate → HCID 178519592、化合物

HRID 1889093

反応式

HRID 1889093 の反応式
F[B-](F)(F)F.C([O+](CC)CC)C.[Cl:13][C:14]1[C:19]([F:20])=[C:18]([Cl:21])[CH:17]=[CH:16][C:15]=1[C:22]([N:24]1[CH2:29][CH2:28][NH:27][C:26](=O)[CH2:25]1)=[O:23].[OH:31][C:32]1[C:37]([C:38]([NH:40][NH2:41])=O)=[CH:36][CH:35]=[CH:34][N:33]=1>ClCCl>[Cl:13][C:14]1[C:19]([F:20])=[C:18]([Cl:21])[CH:17]=[CH:16][C:15]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]2[C:38]([C:37]3[C:32]([OH:31])=[N:33][CH:34]=[CH:35][CH:36]=3)=[N:40][N:41]=[C:26]2[CH2:25]1)=[O:23]

参加物

5

反応物 3

HCID 2723982Triethyloxonium tetrafluoroborateHCID 665993614-[(2,4-Dichloro-3-fluorophenyl)carbonyl]-2-piperazinoneHCID 178514420HCID 178514420、化合物

生成物 1

HCID 178519592HCID 178519592、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Triethyloxonium tetrafluoroborate (215 mg, 1.134 mmol) was added under argon to a solution of 4-[(2,4-dichloro-3-fluorophenyl)carbonyl]-2-piperazinone (I37) (300 mg, 1.031 mmol) in Dichloromethane (DCM) (2.5 mL). The mixture was stirred at room temperature for 1 h 15 min—after 55 min, the mixture became clear. 2-Hydroxy-3-pyridinecarbohydrazide (I92) (189 mg, 1.237 mmol) was added to the solution and the mixture was stirred at room temperature for one day. The solvent was evaporated under reduced pressure and the residue was dissolved in tert-butanol (2.500 mL).

後処理

  1. stirringthe mixture was stirred at room temperature for one day
  2. customThe solvent was evaporated under reduced pressure
  3. dissolutionthe residue was dissolved in tert-butanol (2.500 mL)

出典と根拠

ORDレコード
ord-ba7172281dc548da922454406fcf4914
出典データセット
uspto-grants-2013_08
特許番号
US08501946B2

関連ノート

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