Tert-Butyl nitrite → 1,3-Dibromo-2,5-dichlorobenzene

HRID 1889247ノート

反応式

HRID 1889247 の反応式
[Br:1][C:2]1[C:8]([Cl:9])=[C:7]([Br:10])[CH:6]=[C:5]([Cl:11])[C:3]=1N.N(OC(C)(C)C)=O>CCO>[Br:1][C:2]1[CH:3]=[C:5]([Cl:11])[CH:6]=[C:7]([Br:10])[C:8]=1[Cl:9]

参加物

4

反応物 2

HCID 10906Tert-Butyl nitriteHCID 2625112,4-Dibromo-3,6-dichloroaniline

生成物 1

HCID 140296671,3-Dibromo-2,5-dichlorobenzene

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

A stirred mixture of 2,4-dibromo-3,6-dichloroaniline (5.0 g), tert-Butyl nitrite (3.3 g) and EtOH (50 mL) was heated in a sealed tube at 50° C. for 2 hrs. The mixture was concentrated and the residue was purified by silica gel flash chromatography (hexanes eluant) to afford the title compound. MS m/z: 303 (M+H)+.

後処理

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by silica gel flash chromatography (hexanes eluant)

出典と根拠

ORDレコード
ord-fc2264d5c6d24438b4c9c1f0b2f02322
出典データセット
uspto-grants-2013_08
特許番号
US08501758B2

反応ノート

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