Hydrochloric Acid → HCID 136348338、化合物

HRID 1889447ノート

反応式

HRID 1889447 の反応式
[CH2:1]([C:3]1[S:40][C:6]2[N:7]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]4[NH:38][C:37](=[O:39])[O:36][N:35]=4)=[CH:24][CH:23]=3)[C:8](=[O:20])[N:9]([CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2].[ClH:41]>C(OCC)(=O)C.CC(C)=O>[ClH:41].[CH2:1]([C:3]1[S:40][C:6]2[N:7]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]4[NH:38][C:37](=[O:39])[O:36][N:35]=4)=[CH:24][CH:23]=3)[C:8](=[O:20])[N:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 136052290HCID 136052290、化合物

生成物 1

HCID 136348338HCID 136348338、化合物収率 60%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 8857Ethyl Acetate溶媒

実験手順

6-Ethyl-3-(2-morpholin-4-ylethyl)-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (0.26 g) was dissolved in ethyl acetate (8 mL) and acetone (2 mL), and 4N hydrochloric acid (ethyl acetate solution, 0.11 mL) was added. The precipitated solid was collected by filtration to give the title compound as colorless crystals (0.16. g, 60%).

後処理

  1. filtrationThe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-c0ae2862cef24835a89586b5f3572afa
出典データセット
uspto-grants-2013_08
特許番号
US08501750B2

反応ノート

読み込み中…