Sodium Bicarbonate → 5-(4-Fluorophenoxy)isophthalic acid

HRID 1889645ノート

反応式

HRID 1889645 の反応式
[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:17]([O:19]C)=[O:18])[CH:10]=[C:11]([CH:16]=2)[C:12]([O:14]C)=[O:13])=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+]>CO.O>[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[CH:16]=[C:11]([C:12]([OH:14])=[O:13])[CH:10]=[C:9]([CH:8]=2)[C:17]([OH:19])=[O:18])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 516892Sodium Bicarbonate2 回HCID 66616627Dimethyl 5-(4-fluorophenoxy)isophthalate

生成物 1

HCID 666166365-(4-Fluorophenoxy)isophthalic acid収率 11.6%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A mixture of dimethyl 5-(4-fluorophenoxy)isophthalate (3.8 g, 12.49 mmol) and sodium bicarbonate (1.2 g, 14.28 mmol) in MeOH (100 mL) and water (15 mL) was heated at 80° C. overnight. An additional 500 mg of sodium bicarbonate was added to the reaction mixture and continued to heat at 100° C. for 6 h. HPLC showed a mixture of monoacid (major), diacid (minor) and a small amount of starting material. Prep HPLC provided diacid, 5-(4-fluorophenoxy)isophthalic acid (0.4 g, 1.448 mmol, 11.60% yield) and monoacid, 3-(4-fluorophenoxy)-5-(methoxycarbonyl)benzoic acid (2.2 g, 7.58 mmol, 60.7% yield) as a white solid.

後処理

  1. temperatureto heat at 100° C. for 6 h

出典と根拠

ORDレコード
ord-ae506443b61f419db218e93b5a0e33f3
出典データセット
uspto-grants-2013_08
特許番号
US08501992B2

反応ノート

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