関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | (1-Benzyl-3-trifluoromethyl-pyrrolidin-3-YL)-methanol | HCID 19691277 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Benzyl-3-trifluoromethyl-3-(toluenesulfonyloxymethyl)pyrrolidine | HCID 86750299 | — |
反応手順
The compound from step 456b (1.61 g) was dissolved in dry pyridine, and the solution was cooled to 0° C. To this was added 1.458 g of p-toluenesulfonyl chloride in 4 mL of dry pyridine, and the reaction was stirred at 0.C for 4 days. The mixture was diluted with 300 mL of methylene chloride, then washed with water and brine and dried. Removal of the solvent gave 2.81 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05726182 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-e94dfad47a4a48328c7cf02bef7e5975 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
