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4-Chloro-o-anisic acid → (+/-)-4-Fluoro-2-methoxy-N-(4-oxo-2-pyridin-4-yl-5,6,8,9-tetrahydro-4H-7-oxa-1,4a-diaza-benzocyclohepten-9-yl)-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-o-anisic acid | HCID 93682 | — |
| 反応物 | 4-Fluoro-2-methoxybenzoic acid | HCID 2774545 | — |
| 反応物 | (+/-) 9-Amino-2-pyridin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one | HCID 66846193 | — |
| 生成物 | (+/-)-4-Fluoro-2-methoxy-N-(4-oxo-2-pyridin-4-yl-5,6,8,9-tetrahydro-4H-7-oxa-1,4a-diaza-benzocyclohepten-9-yl)-benzamide | HCID 44159612 | — |
反応手順
By analogy with the method described in example 1 (step 1.4), using (+/−) 9-amino-2-pyridin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one and 4-fluoro-2-methoxy benzoic acid in place of (+/−)-9-amino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one and 4-chloro-2-methoxy-benzoic acid, the compound, 0.068 g (71%), was obtained as a powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08507470B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-7bd987bb57674e3292dae1f2be6e633d |
| 出典メモ | uspto-grants-2013_08 |