p-Toluenesulfonic acid monohydrate → 2-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)one

HRID 1890466

反応式

HRID 1890466 の反応式
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=O)[CH2:11][C:12]1[NH:13][C:14](=[O:24])[CH:15]=[C:16]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[N:17]=1.O.CC1C=CC(S(O)(=O)=O)=CC=1>C1(C)C(C)=CC=CC=1>[CH3:8][C:6]1[CH:5]=[CH:4][C:3]2[N:9]=[C:10]([CH2:11][C:12]3[NH:13][C:14](=[O:24])[CH:15]=[C:16]([N:18]4[CH2:19][CH2:20][O:21][CH2:22][CH2:23]4)[N:17]=3)[O:1][C:2]=2[CH:7]=1

参加物

4

反応物 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 136355295N-(2-hydroxy-4-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide

生成物 1

HCID 1360417612-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)one

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

The product is prepared according to the procedure described in Example 2, using 390 mg of N-(2-hydroxy-4-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide and 108 mg of 4-methylbenzenesulphonic acid hydrate, and replacing the toluene with xylene. After recrystallization from 20 ml of ethanol and 5 ml of methanol, 105 mg of 2-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white solid, the characteristics of which are the following:

後処理

  1. customThe product is prepared
  2. customAfter recrystallization from 20 ml of ethanol and 5 ml of methanol, 105 mg of 2-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one
  3. customare obtained in the form of a white solid

出典と根拠

ORDレコード
ord-0c40b5e1dea5419098b4ebcaf9ea845e
出典データセット
uspto-grants-2013_08
特許番号
US08507483B2

関連ノート

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