Ammonia methanol → Thieno[3,2-b]pyridin-2-ylmethanamine
反応式
Cl[CH2:2][C:3]1[S:11][C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[NH3:12].CO>>[S:11]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[CH2:2][NH2:12]参加物
3
反応条件
- 温度
- 50 °C
実験手順
2-(Chloromethyl)thieno[3,2-b]pyridine (C-5) (183 mg, 1 mmol) was dissolved in NH3/methanol (7 N, 10 mL). The resulting mixture was stirred at 50° C. for 16 hours and concentrated. The residue was purified by chromatography. MS (m/z): 165 (M+1)+.
後処理
- concentrationconcentrated
- customThe residue was purified by chromatography
出典と根拠
- ORDレコード
- ord-616b855999234ff7bc22f07f128c1c85
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507487B2
反応ノート
読み込み中…