Ammonia → HCID 67313715、化合物

HRID 1890580ノート

反応式

HRID 1890580 の反応式
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([C:10]#[N:11])[N:7]=[CH:6][C:5]=12.N>CO.[Ni]>[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH2:10][NH2:11])[N:7]=[CH:6][C:5]=12

参加物

5

反応物 2

HCID 222AmmoniaHCID 67305172Imidazo[1,2-a]pyrazine-6-carbonitrile

生成物 1

HCID 67313715HCID 67313715、化合物収率 86.4%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

To a solution of imidazo[1,2-a]pyrazine-6-carbonitrile (5-1) (180 mg, 1.25 mmol) in methanol (15 mL) were added Raney nickel (slurry in water, 150 mg) and 1 N ammonia. The reaction mixture was stirred under H2 (1 atm) for 2 h. The mixture was filtered, and the filtrate was concentrated to afford the title compound (160 mg). MS (m/z): 149.1 (M+H)+

後処理

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-eb3c409c5f6d4994bc9a39b5bf1f8f09
出典データセット
uspto-grants-2013_08
特許番号
US08507487B2

反応ノート

読み込み中…