Ammonia → (3-Methylimidazo[1,2-a]pyridin-6-yl)methanamine
反応式
[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([C:11]#[N:12])[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.N>CO.[Ni]>[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([CH2:11][NH2:12])[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1参加物
5
実験手順
To a solution of 3-methylimidazo[1,2-a]pyridine-6-carbonitrile (6-2) (200 mg, 1.27 mmol) in methanol (30 mL) were added Raney nickel (slurry in water, 100 mg) and 1N ammonia. The reaction mixture was stirred under H2 for 2 h, then filtered and concentrated to afford the title compound (200 mg). MS (m/z): 162 (M+H)+
後処理
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-5de6c37af71f4cdd9249954e15059d42
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507487B2
反応ノート
読み込み中…