Ammonia → HCID 67306920、化合物
反応式
[CH3:1][O:2][CH2:3][C:4]1[N:8]2[CH:9]=[C:10]([C:13]#[N:14])[CH:11]=[CH:12][C:7]2=[N:6][CH:5]=1.N>CO.[Ni]>[CH3:1][O:2][CH2:3][C:4]1[N:8]2[CH:9]=[C:10]([CH2:13][NH2:14])[CH:11]=[CH:12][C:7]2=[N:6][CH:5]=1参加物
5
実験手順
To a solution of 3-(methoxymethyl)imidazo[1,2-a]pyridine-6-carbonitrile (7-3) (300 mg, 1.6 mmol) in methanol (30 mL) were added Raney nickel (slurry in water, 150 mg) and 1N ammonia. The reaction mixture was stirred under H2 for 2 h. The mixture was filtered. The filtrate was concentrated to afford the title compound (300 mg). MS (m/z): 192.0 (M+H)+
後処理
- filtrationThe mixture was filtered
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-c50fdfb2385f4688a082e8888cbc57bb
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507487B2
反応ノート
読み込み中…