Potassium Fluoride → 4-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)-3-(3-fluorophenyl)morpholine

HRID 1890672ノート

反応式

HRID 1890672 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:13][O:12][CH2:11][CH2:10][NH:9]2)[CH:5]=[CH:6][CH:7]=1.[Br:14][C:15]1[N:19]2[N:20]=[C:21](Cl)[CH:22]=[CH:23][C:18]2=[N:17][CH:16]=1.[F-].[K+]>CS(C)=O>[Br:14][C:15]1[N:19]2[N:20]=[C:21]([N:9]3[CH2:10][CH2:11][O:12][CH2:13][CH:8]3[C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)[CH:22]=[CH:23][C:18]2=[N:17][CH:16]=1

参加物

5

反応物 3

HCID 522689Potassium FluorideHCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazineHCID 583357283-(3-Fluorophenyl)morpholine

生成物 1

HCID 583357794-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)-3-(3-fluorophenyl)morpholine

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
180 °C

実験手順

In step 2-5, a suspension of 3-(3-fluorophenyl)morpholine (1.59 g, 6.9 mmol), 3-bromo-6-chloroimidazo[1,2-b]pyridazine (12-1) (1.5 g, 8.29 mmol) and potassium fluoride (1.6 g, 27.6 mmol) in DMSO (6 mL) was heated at 180° C. for 18 hours while stirring. The resulting solution was cooled to room temperature and purified with HPLC to yield 4-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)-3-(3-fluorophenyl)morpholine (2-5) as a yellow foam.

後処理

  1. temperatureThe resulting solution was cooled to room temperature
  2. custompurified with HPLC

出典と根拠

ORDレコード
ord-74fc6dfe4647454cb5e896e1b9afd4b5
出典データセット
uspto-grants-2013_08
特許番号
US08507488B2

反応ノート

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