Triethylamine → N-[1-(Aminocarbonyl)cyclopentyl]-2-chlorobenzamide

HRID 1890704

反応式

HRID 1890704 の反応式
Cl.[NH2:2][C:3]1([C:8]([NH2:10])=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1.[Cl:11][C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15].C(N(CC)CC)C>C(Cl)Cl>[NH2:10][C:8]([C:3]1([NH:2][C:14](=[O:15])[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[Cl:11])[CH2:7][CH2:6][CH2:5][CH2:4]1)=[O:9]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 691102-Chlorobenzoyl chlorideHCID 545931881-Aminocyclopentane-1-carboxamide hydrochloride

生成物 1

HCID 58550576N-[1-(Aminocarbonyl)cyclopentyl]-2-chlorobenzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 1-aminocyclopentanecarboxamide hydrochloride (0.46 g, 2.79 mmol) in DCM (4 mL), cooled to 0° C., were added 2-chlorobenzoyl chloride (0.73 g, 4.19 mmol) and triethylamine (0.97 mL, 6.99 mmol). After stirring for 3 h, the precipitate in the reaction mixture was filtered to give the title compound.

後処理

  1. filtrationthe precipitate in the reaction mixture was filtered

出典と根拠

ORDレコード
ord-05604bc730ba4c5c973450cc98dcfd6d
出典データセット
uspto-grants-2013_08
特許番号
US08507477B2

関連ノート

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