2-(3-Methyl-2,2'-bipyridin-6-yl)isoindoline-1,3-dione → 3-Methyl-2,2'-bipyridin-6-amine
反応式
[CH3:1][C:2]1[C:3]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[N:4][C:5]([N:8]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:6][CH:7]=1>C(O)C.C(N)CN>[CH3:1][C:2]1[C:3]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[N:4][C:5]([NH2:8])=[CH:6][CH:7]=1参加物
4
実験手順
To a solution of 2-(3-methyl-2,2′-bipyridin-6-yl)isoindoline-1,3-dione (129 mg, 0.41 mmol) in ethanol (2 ml) is added a couple of drops of ethylenediamine at room temperature. The solution is stirred at room temperature for 30 minutes. The solvents are removed by rotary evaporation and the crude product is purified by silica gel flash chromatography, eluted with 3% methanol in dichloromethane to afford 3-methyl-2,2′-bipyridin-6-amine as an off-white solid. LC-MS m/z: 186.1 (M+1).
後処理
- customThe solvents are removed by rotary evaporation
- customthe crude product is purified by silica gel flash chromatography
- washeluted with 3% methanol in dichloromethane
出典と根拠
- ORDレコード
- ord-09e716a1deee478e8eedc157bbcca1a7
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507491B2
反応ノート
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