Cyanamide → Ethyl n-cyano-2-(2,4-difluorophenyl)acetimidate
反応式
Cl.[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[CH2:10][C:11](=[NH:15])[O:12][CH2:13][CH3:14].[N:16]#[C:17]N>C(O)C.C(OCC)C>[C:17]([N:15]=[C:11]([O:12][CH2:13][CH3:14])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([F:9])=[CH:8][C:3]=1[F:2])#[N:16]参加物
5
実験手順
To a solution of Example 4A (7.0 g, 29.7 mmol) in ethanol (100 mL) was added a solution of cyanamide (1.25 g, 29.7 mmol) in diethyl ether (25 mL). The reaction mixture was stirred at room temperature for 3 days. The reaction mixture was then filtered and the filtrate was concentrated to obtain the titled compound. MS (ESI+) m/z 225 (M+H)+.
後処理
- filtrationThe reaction mixture was then filtered
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-a52b5fd28a27437fa5ead5bcf3d479c7
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507493B2
反応ノート
読み込み中…