N,N-dimethyl-1-(3-nitrophenyl)methanesulfonamide → 1-(3-aminophenyl)-N,N-dimethylmethanesulfonamide

HRID 1890976ノート

反応式

HRID 1890976 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][S:11]([N:14]([CH3:16])[CH3:15])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Ni].CO>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][S:11]([N:14]([CH3:16])[CH3:15])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 28632733N,N-dimethyl-1-(3-nitrophenyl)methanesulfonamide

生成物 1

HCID 432562151-(3-aminophenyl)-N,N-dimethylmethanesulfonamide収率 96%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

(3-nitrophenyl)-N,N-dimethylmethanesulfonamide (2.32 g, 9.5 mmol) was hydrogenated over Raney nickel (0.5 g) in methanol at 50° C. and 70 psi for 4 h, then catalyst was filtered off, washed with warm methanol, combined filtrates were evaporated to give 1.95 g (96%) of (3-aminophenyl)-N,N-dimethylmethanesulfonamide.

後処理

  1. filtrationcatalyst was filtered off
  2. washwashed with warm methanol
  3. customwere evaporated

出典と根拠

ORDレコード
ord-95216d08bd9a4a8a8340c3376e4a882b
出典データセット
uspto-grants-2013_08
特許番号
US08507498B2

反応ノート

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