HCID 24902159、化合物 → HCID 25132978、化合物
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][S:9]([NH-:12])(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.Cl[C:14]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH2:26][CH3:27])[N:17]=[CH:16][N:15]=1>CN(C=O)C>[CH2:26]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:18]1[N:17]=[CH:16][N:15]=[C:14]([NH:1][C:2]2[CH:3]=[C:4]([CH2:8][S:9]([NH2:12])(=[O:10])=[O:11])[CH:5]=[CH:6][CH:7]=2)[CH:19]=1)[CH3:27]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of (3-aminophenyl)methanesulfonyl amide (0.112 g, 0.60 mmol) and 4-chloro-6-(2-ethylphenyl)-pyrimidine (0.131 g, 0.60 mmol) in DMFA (3 mL) was stirred at 80° C. till the reaction completion (TLC control), then concentrated in vacuo, and the residue was recrystallized from isopropanol to give {3-[6-(2-ethyl-phenyl)-pyrimidin-4-ylamino]-phenyl}-methanesulfonamide (Compound 26)