HCID 86644565、化合物 → HCID 68486762、化合物
反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([C:15]2[N:20]=[C:19]([C:21]3[CH:47]=[CH:46][CH:45]=[C:44]([F:48])[C:22]=3[O:23][CH2:24][C:25]3[CH:30]=[CH:29][C:28]([CH:31]4[CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33][CH2:32]4)=[CH:27][CH:26]=3)[CH:18]=[CH:17][CH:16]=2)[C:10]=1[C:11]([F:14])([F:13])[F:12])=[O:5])[CH3:2]>C(O)(=O)C.O>[F:48][C:44]1[C:22]([O:23][CH2:24][C:25]2[CH:26]=[CH:27][C:28]([CH:31]3[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]3)=[CH:29][CH:30]=2)=[C:21]([C:19]2[N:20]=[C:15]([N:9]3[C:10]([C:11]([F:13])([F:14])[F:12])=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]=[N:8]3)[CH:16]=[CH:17][CH:18]=2)[CH:47]=[CH:46][CH:45]=1参加物
4
実験手順
A solution of the title compound from Example 5 Step B (800 mg, 1.20 mmol) in acetic acid (4 mL) and water (1 mL) was stirred at 90° C. for 14 h. The reaction mixture was allowed to cool to ambient temperature and evaporated in vacuo. The product was used in the subsequent step without further purification: LCMS m/z 568.8 [M+H]+.
後処理
- customevaporated in vacuo
- custom