Tetrabutylammonium Fluoride → {3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol

関与物質

反応手順

210 mg of 6-[3-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-α]pyridine in 5 ml of tetrahydrofuran are placed in a round-bottomed flask and 240 mg of tetrabutylammonium fluoride are added thereto. The mixture is stirred at ambient temperature for 48 h. The reaction mixture is then concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. 130 mg of compound are obtained.

情報源と証拠