Hydrochloric Acid → {3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol hydrochloride

HRID 1891240ノート

反応式

HRID 1891240 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[C:19]([CH2:23][OH:24])[CH:20]=[CH:21][CH:22]=3)=[CH:13][N:12]2[C:25]=1[CH3:26].[ClH:27]>ClCCl.CO.C(O)(C)C>[ClH:27].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[C:19]([CH2:23][OH:24])[CH:20]=[CH:21][CH:22]=3)=[CH:13][N:12]2[C:25]=1[CH3:26]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 44233767{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol

生成物 1

HCID 44233766{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol hydrochloride

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 3776Isopropanol溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 130 mg of {3-[2-(2,4-difluorophenyl)-3-methylimidazo[1,2-α]pyridin-6-yl]phenyl}methanol in dichloromethane and methanol is passed through a frit and 3.7 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure. The residue obtained is triturated from diethyl ether and recovered by filtration and then oven-dried under reduced pressure. 128 mg of compound are obtained.

後処理

  1. additionare added to the filtrate
  2. concentrationThe reaction mixture is then concentrated under reduced pressure
  3. customThe residue obtained
  4. customis triturated from diethyl ether
  5. filtrationrecovered by filtration
  6. customoven-dried under reduced pressure

出典と根拠

ORDレコード
ord-aab69326ba28499b866b5beeba3ca10a
出典データセット
uspto-grants-2013_08
特許番号
US08507520B2

反応ノート

読み込み中…