Hydrochloric Acid → 2-Amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol

3-Methyl-3prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane (1.83 g) in an aqueous solution of HCl (6N) (2.73 ml) were refluxed for 1 hr. The reaction mixture was cooled down to room temperature, diluted with water and extracted thrice with ethyl ether. The two layers were separated. The aqueous layer was concentrated under reduced pressure and further co-evaporated with toluene to yield 2-amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol hydrochloric salt (1.205 g) as a white beige solid which was used in the next step without any further purification.

1. extractionextracted thrice with ethyl ether
2. customThe two layers were separated
3. concentrationThe aqueous layer was concentrated under reduced pressure and further co-evaporated with toluene

ORDレコード

ord-4a2ffbaad6f44822a495c36fe6bd05f5

出典データセット

uspto-grants-2013_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08507509B2