Methanesulfonamide → N-(Diphenoxymethylene)-methanesulfonamide
反応式
Cl[C:2](Cl)([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:18][S:19]([NH2:22])(=[O:21])=[O:20]>CCOC(C)=O>[CH3:18][S:19]([N:22]=[C:2]([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:21])=[O:20]参加物
4
実験手順
Dichlorodiphenoxymethane (2 g, 7.46 mmol) and methylsulfonamide (1.56 g, 16.41 mmol) were dissolved in EtOAc (15 ml) and heated to reflux for 12 hours. The mixture was allowed to cool and was concentrated under vacuum. Purification of the crude mixture by flash chromatography (20% EtOAc/hexanes) afforded diphenyl methylsulfonylcarbonimidate (0.75 g, 2.59 mmol, 35%).
後処理
- temperatureheated
- temperatureto reflux for 12 hours
- temperatureto cool
- concentrationwas concentrated under vacuum
- customPurification of the crude mixture by flash chromatography (20% EtOAc/hexanes)
出典と根拠
- ORDレコード
- ord-ba0a139c0cc145c4b92af88b1ebbac74
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507672B2
反応ノート
読み込み中…