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N,N'-Dicyclohexylurea → N'-(6-Chloropyridazin-3-yl)-2-(quinolin-6-yl)acetohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N'-Dicyclohexylurea | HCID 4277 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 3-Chloro-6-hydrazinopyridazine | HCID 100787 | — |
| 反応物 | 2-(Quinolin-6-yl)acetic acid | HCID 11788709 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N'-(6-Chloropyridazin-3-yl)-2-(quinolin-6-yl)acetohydrazide | HCID 86652010 | — |
反応手順
To a suspension of 3-chloro-6-hydrazinylpyridazine (3 g, 20.75 mmol) and 2-(quinolin-6-yl)acetic acid (4.27 g, 22.83 mmol) in DCM (200 mL) was added DCC (5.14 g, 24.90 mmol). The solution was stirred at it over weekend. The title compound as a white solid containing some dicyclohexyl urea was collected and used in the next step without further purification (8 g, 100%). LCMS (method A): [MH]+=314.1, tR=2.851 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08507676B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-d353ff8751a240e4af9c2fd6e4a1249e |
| 出典メモ | uspto-grants-2013_08 |