Ammonia → 3-(1,1-Dimethylethylsulfinamido)oxetane-3-carboximidamide
反応式
[C:1]([C:3]1([NH:7][S:8]([C:10]([CH3:13])([CH3:12])[CH3:11])=[O:9])[CH2:6][O:5][CH2:4]1)#[N:2].C([NH:17][C@H](C(O)=O)CS)(=O)C.N>CO>[CH3:11][C:10]([CH3:13])([S:8]([NH:7][C:3]1([C:1](=[NH:17])[NH2:2])[CH2:4][O:5][CH2:6]1)=[O:9])[CH3:12]参加物
5
実験手順
To a mixture of N-(3-cyanooxetan-3-yl)-2-methylpropane-2-sulfinamide (0.1 g, 0.494 mmol) in methanol (2 ml) in a 50 ml sealed tube was added N-acetyl-L-(+)-cysteine (0.081 g, 0.494 mmol), and the reaction mixture stirred for few minutes. A solution of ammonia in methanol (0.5 ml, 3.50 mmol, 7 N) was added, and the reaction mixture stirred at 60° C. for overnight. The reaction mixture was then concentrated under vacuum, and the crude was used for the next step without further purification.
後処理
- customsealed tube
- stirringthe reaction mixture stirred at 60° C. for overnight
- concentrationThe reaction mixture was then concentrated under vacuum
- customthe crude was used for the next step without further purification
出典と根拠
- ORDレコード
- ord-389ccd3d7dcf458e8eba9b9d99eab6d4
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507683B2
反応ノート
読み込み中…