Hydrochloric Acid → 5-Morpholinopicolinic acid

HRID 1892583ノート

反応式

HRID 1892583 の反応式
N1([C:7]([C:9]2[N:14]=[CH:13][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:11][CH:10]=2)=[O:8])CCCCC1.Cl.[OH-:22].[K+]>>[O:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:11]=[CH:10][C:9]([C:7]([OH:8])=[O:22])=[N:14][CH:13]=2)[CH2:16][CH2:17]1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 671512274-[6-(Piperidin-1-ylcarbonyl)pyridin-3-yl]morpholine

生成物 1

HCID 582525805-Morpholinopicolinic acid収率 71%

実験手順

25% KOH (100 mL) was added to 4-[6-(piperidin-1-ylcarbonyl)pyridin-3-yl]morpholine (183 g), and the mixture was refluxed and then neutralized with HCl. The solution was evaporated in vacuum, and the product was extracted with hot isopropanol to give the title compound (yield 71%, 11.5 g). +ESI MS (M+H) 209.7; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.34 (br, s., 1H), 8.03 (d, 1H), 7.65 (dd, 1H), 3.75 (br, s., 4H), 3.40 (br, s., 4H).

後処理

  1. temperaturethe mixture was refluxed
  2. customThe solution was evaporated in vacuum
  3. extractionthe product was extracted with hot isopropanol

出典と根拠

ORDレコード
ord-8f88d5d3dfc248af959e4391ce8f5bff
出典データセット
uspto-grants-2013_08
特許番号
US08507681B2

反応ノート

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