反応式
C1C(C(N[C@H](C(O)=O)CCC(O)=O)=[O:8])=CC=C(NCC2N=C3C(N=C(N)NC3=NC=2)=O)C=1.[CH2:33]1[CH2:38][CH2:37][CH:36]([N:39]=[C:40]=[N:41][CH:42]2[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]2)[CH2:35][CH2:34]1>CS(C)=O>[C:40]([NH:39][CH:36]1[CH2:35][CH2:34][CH2:33][CH2:38][CH2:37]1)([NH:41][CH:42]1[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1)=[O:8]参加物
4
実験手順
The carboxylic acid group of folic add (1.0 g, 2 mmol) dissolved in 20 mL of DMSO was pre-activated with DCC (0.495 g, 2.4 mmol) and NHS (0.463 g 4 mmol) at room temperature (Scheme 2). In the reaction, dicyclohexylurea was formed and removed by filtration. The vacuum-dried precursor polymer was added to the reaction solution. The reaction was kept at room temperature for 48 hours. The resulting solution was placed in a dialysis membrane with a molecular weight cut-off of 2000 and dialyzed against DI water for one week. The final product was harvested by freeze-drying.
後処理
- customIn the reaction
出典と根拠
- ORDレコード
- ord-1d0f465130cd425f9118beddab22a673
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08512757B2
関連ノート
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