Chlorosuccinimide → 2,3-Dichloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

HRID 1893424ノート

反応式

HRID 1893424 の反応式
[Cl:1][C:2]1[N:6]2[CH2:7][CH2:8][N:9]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[O:12])[CH2:10][C:5]2=[N:4][CH:3]=1.C1C(=O)N([Cl:28])C(=O)C1>CN(C)C=O>[Cl:28][C:3]1[N:4]=[C:5]2[CH2:10][N:9]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[O:12])[CH2:8][CH2:7][N:6]2[C:2]=1[Cl:1]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 497855443-Chloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

生成物 1

HCID 497853692,3-Dichloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3-Chloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (E44) (300 mg, 0.907 mmol) and NCS (133 mg, 0.998 mmol) were stirred at RT for 16 h in N,N-dimethylformamide (DMF) (2 mL). Solvents were removed in vacuo and the residue was purified by MDAP to afford desired product in 218 mg.

後処理

  1. customSolvents were removed in vacuo
  2. customthe residue was purified by MDAP

出典と根拠

ORDレコード
ord-618783c4af4f40a796e4693773344cd3
出典データセット
uspto-grants-2013_08
特許番号
US08513248B2

反応ノート

読み込み中…