2-Nitroso-1,2,3,4-tetrahydroisoquinoline → N-methyl-3,4-dihydro-1H-isoquinolin-2-amine

反応式

[CH2:1]=[N:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1.N(N1CCC2C(=CC=CC=2)C1)=O>>[CH3:1][NH:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1

参加物

反応物 2

HCID 122768662-Nitroso-1,2,3,4-tetrahydroisoquinoline

HCID 66881110HCID 66881110、化合物

生成物 1

HCID 409505N-methyl-3,4-dihydro-1H-isoquinolin-2-amine収率 95%

実験手順

Using N-methylene-3,4-dihydroisoquinolin-2 (1H)-amine and the compound (3.00 g, 18.5 mmol) obtained in step A, and according to the method of Reference Example 37, step B, the title compound (2.86 g, yield 95%) was obtained as a pale-yellow oil.

出典と根拠

ORDレコード: ord-6058bc7855034e9f8089b71b0a4a8537
出典データセット: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08513235B2

反応ノート

読み込み中…