Hydrogen chloride-ethyl acetate → HCID 66881276、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]([NH:11]C(=O)OC(C)(C)C)[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[ClH:19].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:19].[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1参加物
4
実験手順
The compound (6.27 g, 20.0 mmol) obtained in step A was dissolved in ethyl acetate, 4N hydrochloric acid-ethyl acetate solution (25 ml, 100 mmol) was added at room temperature with stirring, and the mixture was stirred at the same temperature overnight. The precipitated solid was filtered, washed with ethyl acetate, and dried under reduced pressure to give the title compound (4.65 g, yield 93%) as a colorless solid.
後処理
- stirringthe mixture was stirred at the same temperature overnight
- filtrationThe precipitated solid was filtered
- washwashed with ethyl acetate
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-bd3bedd2808c48d599b9de5c7b2ec225
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08513235B2
反応ノート
読み込み中…