Sulfamic acid 1-ethyl-cyclopropyl ester → 2-[2-Ethyl-1-(1-ethyl-cyclopropoxysulfonylaminocarbonyl)-cyclopropylcarbamoyl]-4-(6-methoxy-isoquinolin-1-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
反応式
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([O:13][C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:24][CH3:25])=[CH:21][CH:22]=3)[CH:17]=[CH:16][N:15]=2)[CH2:10][CH:9]1[C:26](=[O:36])[NH:27][C:28]1([C:33](O)=[O:34])[CH2:30][CH:29]1[CH2:31][CH3:32])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:37]([C:39]1([O:42][S:43](=[O:46])(=[O:45])[NH2:44])[CH2:41][CH2:40]1)[CH3:38]>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([O:13][C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:24][CH3:25])=[CH:21][CH:22]=3)[CH:17]=[CH:16][N:15]=2)[CH2:10][CH:9]1[C:26](=[O:36])[NH:27][C:28]1([C:33]([NH:44][S:43]([O:42][C:39]2([CH2:37][CH3:38])[CH2:41][CH2:40]2)(=[O:46])=[O:45])=[O:34])[CH2:30][CH:29]1[CH2:31][CH3:32])=[O:7])([CH3:2])([CH3:3])[CH3:4]参加物
3
反応物 2
生成物 1
実験手順
2-[2-Ethyl-1-(1-ethyl-cyclopropoxysulfonylaminocarbonyl)-cyclopropylcarbamoyl]-4-(6-methoxy-isoquinolin-1-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared according to the method presented in Example 27. Treatment of 2-(1-carboxy-2-ethyl-cyclopropylcarbamoyl)-4-(6-methoxy-isoquinolin-1-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.70 mmol) occurred under the same conditions, adjusted for scale with the exception of utilizing sulfamic acid 1-ethyl-cyclopropyl ester to afford the desired acylsulfamate (230 mg, 51%): LCMS found 647.1 [M+H]+.