2-Amino-2-cyclopropylacetic acid → HCID 68616869、化合物

反応式

C[C:2]([CH3:17])([CH3:16])[CH:3]([NH:7][C:8]([O:10][CH:11]1[CH2:15][CH2:14][O:13][CH2:12]1)=[O:9])[C:4]([OH:6])=[O:5].NC(C1CC1)C(O)=O.O1CCC(OC(=O)OC2C=CC([N+]([O-])=O)=CC=2)C1>>[CH:2]1([CH:3]([NH:7][C:8]([O:10][CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[O:9])[C:4]([OH:6])=[O:5])[CH2:16][CH2:17]1

参加物

反応物 3

HCID 41122502-Amino-2-cyclopropylacetic acid

HCID 15343685HCID 15343685、化合物

HCID 66749849HCID 66749849、化合物

生成物 1

HCID 68616869HCID 68616869、化合物

実験手順

Cyclopropyl-[(tetrahydro-furan-3-yloxycarbonylamino)]-acetic acid was prepared according to the method presented in the synthesis of the intermediate 3,3-dimethyl-2-(tetrahydro-furan-3-yloxycarbonylamino)-butyric acid in Example 62. Treatment of amino-cyclopropyl-acetic acid with carbonic acid 4-nitro-phenyl ester tetrahydro-furan-3-yl ester occurred under the same conditions, adjusted for scale, to provide the desired cyclopropyl-[(tetrahydro-furan-3-yloxycarbonylamino)]-acetic acid.

後処理

customCyclopropyl-[(tetrahydro-furan-3-yloxycarbonylamino)]-acetic acid was prepared

出典と根拠

ORDレコード: ord-bb30a1c4f5b945f9938f378593df11db
出典データセット: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08513186B2

反応ノート

読み込み中…