Sulfuric Acid → HCID 67331500、化合物

HRID 1893784ノート

反応式

HRID 1893784 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:19]=[CH:18][N:17]2[N:20]=[CH:21][C:22]([NH:23][C:24]([N:26]3[CH2:29][CH:28]([O:30][CH3:31])[CH2:27]3)=[O:25])=[C:16]2[N:15]=1.[S:32](=[O:36])(=[O:35])([OH:34])[OH:33]>CO>[S:32]([OH:36])([OH:35])(=[O:34])=[O:33].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:19]=[CH:18][N:17]2[N:20]=[CH:21][C:22]([NH:23][C:24]([N:26]3[CH2:27][CH:28]([O:30][CH3:31])[CH2:29]3)=[O:25])=[C:16]2[N:15]=1

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 58386276(R)-N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-methoxyazetidine-1-carboxamide

生成物 1

HCID 67331500HCID 67331500、化合物収率 94%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of (R)—N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-methoxyazetidine-1-carboxamide (6.2 mg, 0.014 mmol) in methanol (1 mL) at ambient temperature was added sulfuric acid in methanol (145 μL, 0.014 mmol). The resulting solution was stirred for 30 minutes then concentrated to provide (R)—N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-methoxyazetidine-1-carboxamide sulfate (7.2 mg, 0.014 mmol, 94% yield) as a yellow solid.

後処理

  1. concentrationthen concentrated

出典と根拠

ORDレコード
ord-6780ea0639a742858bb92ce9e221592b
出典データセット
uspto-grants-2013_08
特許番号
US08513263B2

反応ノート

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