Boron tribromide → N,N-Diethyl-3-hydroxybenzamide
反応式
[CH2:1]([N:3]([CH2:14][CH3:15])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11]C)[CH:6]=1)[CH3:2].B(Br)(Br)Br>C(Cl)Cl>[CH2:14]([N:3]([CH2:1][CH3:2])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[CH:6]=1)[CH3:15]参加物
4
実験手順
To a solution of Compound 15a (0.68 g; 3.28 mmol) in CH2Cl2 (50 mL) was added BBr3 (1.0M in CH2Cl2) (16 mL; 16 mmol) dropwise at 0° C. The reaction was stirred at room temperature for 1 h. The mixture was quenched with saturated aqueous NaHCO3. The organic layer was dried over MgSO4 and concentrated to afford Compound 15b. The crude product was used in the next reaction without further purification. MS m/z 194.2 (M+H)+.
後処理
- customThe mixture was quenched with saturated aqueous NaHCO3
- dry with materialThe organic layer was dried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-e2d39c1d830c4dd68885677bb4c0d4b3
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08513271B2
反応ノート
読み込み中…