Hydrochloric Acid → HCID 58679182、化合物
反応式
[Cl:1][C:2]1[C:10]2[O:9][CH2:8][O:7][C:6]=2[CH:5]=[CH:4][C:3]=1[NH:11]C(=O)OC(C)(C)C.Cl.O1CCOCC1>>[Cl:1][C:2]1[C:10]2[O:9][CH2:8][O:7][C:6]=2[CH:5]=[CH:4][C:3]=1[NH2:11]参加物
4
実験手順
To a vial containing tert-butyl 4-chlorobenzo[d][1,3]dioxol-5-ylcarbamate (307.2 mg, 1.1 mmol, 1 equiv.) was added 5.5 mL of 4N HCl in dioxane (22 mmol, 20 equiv.). The mixture was stirred at room temperature for 5.5 h, the solvent removed under vacuum, the residue dissolved in ethyl acetate, washed with saturated NaHCO3, and brine. The combined organic layers was dried over anhydrous Na2SO4, filtered and the solvent removed under to give a quantitative yield 4-chlorobenzo[d][1,3]dioxol-5-amine.
後処理
- customthe solvent removed under vacuum
- dissolutionthe residue dissolved in ethyl acetate
- washwashed with saturated NaHCO3, and brine
- dry with materialThe combined organic layers was dried over anhydrous Na2SO4
- filtrationfiltered
- customthe solvent removed under
出典と根拠
- ORDレコード
- ord-7c8cd4f5f76c48d0a289af1b2b2d81b3
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741479B2
反応ノート
読み込み中…