Hydrochloric Acid → 4-(Methanesulfonylmethyl)piperidine hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][S:15]([CH3:18])(=[O:17])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19]>>[ClH:19].[CH3:18][S:15]([CH2:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)(=[O:17])=[O:16]参加物
3
実験手順
4-Methanesulfonylmethyl-piperidine-1-carboxylic acid tert-butyl ester as white solid (6 g) was suspended in hydrochloric acid (4N solution in 1,4-dioxane) at 0° C. The ice bath was removed and the mixture was stirred at room temperature overnight. It was concentrated to give 4-methanesulfonylmethyl-piperidine hydrochloride as white solid (4.52 g).
後処理
- customThe ice bath was removed
- concentrationIt was concentrated
出典と根拠
- ORDレコード
- ord-6ce130868a6848abad48a830afdcb77e
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08513239B2
反応ノート
読み込み中…