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HRID 1894414作成日：2026年10月27日

1-(3-Methoxypropyl)piperazine → [(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methoxy-propyl)-piperazin-1-yl]-methanone

https://huagongshe.com/reaction/1894414

反応式

関与物質

役割名称HCID仕込み量
反応物1-(3-Methoxypropyl)piperazineHCID 1822536—
反応物(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 57669958—
生成物[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methoxy-propyl)-piperazin-1-yl]-methanoneHCID 57670088—

反応手順

In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with 1-(3-methoxy-propyl)-piperazine (Oakwood) to give the title compound. HR-MS (ES, m/z) calculated for C37H48Cl2N5O3 [(M+H)+] 680.3129, observed 680.3133.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08513239B2
出典データセットuspto-grants-2013_08
ORD IDord-c4511e33ab7e40ed98c9d5d68bb933fb
出典メモuspto-grants-2013_08