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HRID 1894415作成日：2026年10月27日

Thiomorpholine 1,1-dioxide → 2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-ethanone

https://huagongshe.com/reaction/1894415

反応式

関与物質

役割名称HCID仕込み量
反応物Thiomorpholine 1,1-dioxideHCID 6484228—
反応物{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochlorideHCID 25262898—
生成物2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-ethanoneHCID 25262737—

反応手順

In a manner analogous to the method described in examples 99, {4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochloride (example 94) was coupled with thiomorpholine 1,1-dioxide (Syntech Development) to give the title compound. HR-MS (ES, m/z) calculated for C39H49Cl2N6O5S [(M+H)+] 783.2857, observed 783.2856.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08513239B2
出典データセットuspto-grants-2013_08
ORD IDord-2f18a2545cbe49f585cbf8f5dc6c2c07
出典メモuspto-grants-2013_08