戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1894417作成日：2026年10月27日

1,4-Diazepan-5-one → 1-(2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetyl)-[1,4]diazepan-5-one

https://huagongshe.com/reaction/1894417

反応式

関与物質

役割名称HCID仕込み量
反応物1,4-Diazepan-5-oneHCID 2737264—
反応物{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochlorideHCID 25262898—
生成物1-(2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetyl)-[1,4]diazepan-5-oneHCID 57670132—

反応手順

In a manner analogous to the method described in examples 99, {4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochloride (example 94) was coupled with [1,4]diazepan-5-one (Oakwood Products) to give the title compound. HR-MS (ES, m/z) calculated for C40H50Cl2N7O4 [(M+H)+] 762.3296, observed 762.3297.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08513239B2
出典データセットuspto-grants-2013_08
ORD IDord-b618b05cab2f4ece8ea5a3369d233efc
出典メモuspto-grants-2013_08