戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1894425作成日：2026年10月27日

N-Methylisopropylamine → 2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-isopropyl-N-methyl-acetamide

https://huagongshe.com/reaction/1894425

反応式

関与物質

役割名称HCID仕込み量
反応物N-MethylisopropylamineHCID 78485—
反応物{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochlorideHCID 25262898—
生成物2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-isopropyl-N-methyl-acetamideHCID 25262431—

反応手順

In a manner analogous to the method described in examples 99, {4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochloride (example 94) was coupled with isopropyl-methyl-amine (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C39H51Cl2N6O3 [(M+H)+] 721.3394, observed 721.3399.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08513239B2
出典データセットuspto-grants-2013_08
ORD IDord-6df521d449094ab79d75dd4ac39f2fc7
出典メモuspto-grants-2013_08