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HRID 1894426作成日：2026年10月27日

Tert-Butylamine → N-tert-Butyl-2-{4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetamide

https://huagongshe.com/reaction/1894426

反応式

関与物質

役割名称HCID仕込み量
反応物Tert-ButylamineHCID 6385—
反応物{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochlorideHCID 25262898—
生成物N-tert-Butyl-2-{4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetamideHCID 25262430—

反応手順

In a manner analogous to the method described in examples 99, {4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochloride (example 94) was coupled with tert-butylamine (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C39H51Cl2N6O3 [(M+H)+] 721.3394, observed 721.3399.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08513239B2
出典データセットuspto-grants-2013_08
ORD IDord-a26cc03eda7e46869d84ab1940550ef0
出典メモuspto-grants-2013_08