Sodium Bicarbonate → HCID 86681898、化合物
反応式
[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH2:11][CH2:12][CH2:13][CH3:14])[CH:8]=[CH:7][C:5]=2[N:6]=1.C(=O)(O)[O-:16].[Na+]>C(O)(=O)C>[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([C:11](=[O:16])[CH2:12][CH2:13][CH3:14])[CH:8]=[CH:7][C:5]=2[N:6]=1参加物
4
実験手順
To a solution of 2-bromo-6-butylbenzo[d]thiazole in acetic acid at 0° C. was added CrO3 in acetic acid. The reaction mixture was allowed to warm to RT and stirred over 2 days. The reaction was neutralized by aq. sodium bicarbonate and extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by preparative TLC to afford 1-(2-bromobenzo[d]thiazol-6-yl)butan-1-one. MS (ESI m/z 286.2 [M+2]
後処理
- extractionextracted with ethyl acetate
- washwashed with brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated
- customThe crude product was purified by preparative TLC
出典と根拠
- ORDレコード
- ord-40e937919b624ac8b40e107f3f1bad5f
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08513291B2
反応ノート
読み込み中…