Ammonia → HCID 59436157、化合物

HRID 1895086ノート

反応式

HRID 1895086 の反応式
[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:4]=[C:3]1[C:18]([O:20]C)=O.[NH3:22]>>[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:4]=[C:3]1[C:18]([NH2:22])=[O:20]

参加物

3

反応物 2

HCID 222AmmoniaHCID 1481306HCID 1481306、化合物

生成物 1

HCID 59436157HCID 59436157、化合物収率 64%

反応条件

温度
100 °C

実験手順

A solution of methyl 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate (1.007 g, 3.38 mmol) in ammonia (7 N in MeOH, 12 mL, 84 mmol) was heated under microwave heating conditions at 100° C. for 5 min. After that time the reaction was cooled to room temperature and concentrated to give a yellow solid. This was recrystallized from EtOAc to give 0.613 g (64%) of 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxamide as colorless crystals.

後処理

  1. temperatureAfter that time the reaction was cooled to room temperature
  2. concentrationconcentrated
  3. customto give a yellow solid
  4. customThis was recrystallized from EtOAc

出典と根拠

ORDレコード
ord-11fa6ea784c2437dabf5b705770b971c
出典データセット
uspto-grants-2013_08
特許番号
US08513251B2

反応ノート

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