Bromopyruvic Acid → 2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid

HRID 1895397ノート

反応式

HRID 1895397 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH2:11])=[S:10])=[CH:4][CH:3]=1.Br[CH2:13][C:14](=O)[C:15]([OH:17])=[O:16]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]2[S:10][CH:13]=[C:14]([C:15]([OH:17])=[O:16])[N:11]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 70684Bromopyruvic AcidHCID 7358434-Chlorophenyl-2-thiourea

生成物 1

HCID 27577622-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid収率 94.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid (240 mg) was prepared according to General Procedure B using (4-chloro-phenyl)-thiourea (186 mg) and 3-bromo-2-oxo-propionic acid (200 mg) in methanol (2 mL). The crude product was used in a subsequent step without further purification.

後処理

  1. customThe crude product was used in a subsequent step without further purification

出典と根拠

ORDレコード
ord-48f6c1b7cbb24a1e9a7ea9876560e3d4
出典データセット
uspto-grants-2013_08
特許番号
US08513430B2

反応ノート

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