Bromopyruvic Acid → 2-(3,4-Dichloroanilino)-1,3-thiazole-4-carboxylic acid

HRID 1895399

反応式

HRID 1895399 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([NH2:12])=[S:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Br[CH2:14][C:15](=O)[C:16]([OH:18])=[O:17]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[S:11][CH:14]=[C:15]([C:16]([OH:18])=[O:17])[N:12]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 70684Bromopyruvic AcidHCID 710776N-(3,4-Dichlorophenyl)thiourea

生成物 1

HCID 242138602-(3,4-Dichloroanilino)-1,3-thiazole-4-carboxylic acid収率 95.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(3,4-Dichloro-phenylamino)-thiazole-4-carboxylic acid (275 mg) was prepared according to General Procedure B using (3,4-dichloro-phenyl)-thiourea (220 mg) and 3-bromo-2-oxo-propionic acid (200 mg) in methanol (2 mL). The crude product was used in a subsequent step without further purification.

後処理

  1. customThe crude product was used in a subsequent step without further purification

出典と根拠

ORDレコード
ord-e04cea16fea34da191b2528d6ca902ee
出典データセット
uspto-grants-2013_08
特許番号
US08513430B2

関連ノート

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