化工社化工社 化学情報印刷レポート · 研究参考用
Phosphorus oxychloride → 1-Chloro-6-methoxy-3-methylisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 6-Methoxy-3-methylisoquinolin-1(2H)-one | HCID 12327060 | — |
| 生成物 | 1-Chloro-6-methoxy-3-methylisoquinoline | HCID 57893095 | — |
反応手順
Isoquinoline-1-one 43 was dissolved in POCl3 (2.5 mL) and heated at reflux for 1 h. The excess POCl3 was removed in vacuo and the residue was dissolved in CHCl3. The resulting solution was washed with 1N aq. NaOH, water and saturated ag. NaCl. Evaporation of the solvent gave crude 44 which was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08518874B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-834bf06d1b42452fa9412b9fc8ede38d |
| 出典メモ | uspto-grants-2013_08 |