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2-Chloro-6-methyl-3-nitropyridine → 6-Methyl-2-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-6-methyl-3-nitropyridine | HCID 1268230 | — |
| 反応物 | 2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine | HCID 87550402 | — |
| 生成物 | 6-Methyl-2-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine | HCID 25147508 | 54.8% |
反応手順
A well homogenised mixture of the Compound of Example 3 (23 mg, 0.11 mmol) and 6-chloro-5-nitro-2-picoline (26.2 mg, 0.15 mmol) was stirred at 120° C. for 0.5 h. The reaction crude was purified by flash chromatography (EtOAc—Petroleum Ether gradient from 3:7 to 4:6) affording the title product (21 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08518916B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-eecdb9d2fa4f4167b12bd36a3a080539 |
| 出典メモ | uspto-grants-2013_08 |