Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylate → 5-(3-Piperidin-4-ylideneprop-1-ynyl)pyridine-2-carbonitrile

HRID 1895968

反応式

HRID 1895968 の反応式
C[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[C:9][CH:10]=[C:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[N:3]=1.[C:17](C1C=C(C#CC=C2CCN(C(OC(C)(C)C)=O)CC2)C=NC=1)#[N:18]>>[NH:14]1[CH2:13][CH2:12][C:11](=[CH:10][C:9]#[C:8][C:4]2[CH:5]=[CH:6][C:7]([C:2]#[N:3])=[N:18][CH:17]=2)[CH2:16][CH2:15]1

参加物

3

反応物 2

HCID 25183829Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

生成物 1

HCID 875497035-(3-Piperidin-4-ylideneprop-1-ynyl)pyridine-2-carbonitrile

実験手順

The title compounds were prepared following the procedure described for the compound of Example 3 but starting respectively from the compounds of Example 45 and 46 instead of the compound of Example 2. The crudes were used in the next step without further purification.

後処理

  1. customThe crudes were used in the next step without further purification

出典と根拠

ORDレコード
ord-77ce2b0e472a4b3587e90754b2777946
出典データセット
uspto-grants-2013_08
特許番号
US08518916B2

関連ノート

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