Tert-butyl 4-[1-hydroxy-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylate → 3-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol

HRID 1895992ノート

反応式

HRID 1895992 の反応式
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[OH:17][CH:18]([CH:28]1[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]1)[C:19]#[C:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[N:22]=1>>[CH3:27][C:23]1[N:22]=[C:21]([C:20]#[C:19][CH:18]([CH:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[OH:17])[CH:26]=[CH:25][CH:24]=1

参加物

3

反応物 2

HCID 68725592Tert-butyl 4-[1-hydroxy-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

生成物 1

HCID 689774953-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol

実験手順

The title compound was prepared following the procedure described for the compound of Example 3, using the Compound of Example 39 instead of the Compound of Example 2. After the usual work-up procedure, the crude was used in the next step without further purification.

後処理

  1. customAfter the usual work-up procedure, the crude was used in the next step without further purification

出典と根拠

ORDレコード
ord-4517455cfc04487fa2d27d7eb5470dec
出典データセット
uspto-grants-2013_08
特許番号
US08518916B2

反応ノート

読み込み中…